At the crossroads of environmental and health policies, the monitoring and regulation of indoor air quality rely heavily on the production of technical and scientific knowledge, mainly in toxicology and environmental risk assessment. This paper focuses on the emergence of this policy in Europe over the last 20 years and the introduction of a series of government tools from exposure value limits to product labelling and public health surveillance system. Using interviews and archives, we argue that the structural orientation of this policy resulted from the building of a specific transnational scientific network which legitimized and formatted state intervention but also contributed to depoliticize the issue of chemical pollutions. In addition, we focus at the national level on the role of the community of scientists and regulatory experts, mainly embedded in state french bureaucracies, which produced this policy-relevant knowledge.