The paper looks at regionalist parties (as well as state-wide with regionalist agenda) in historic regions of Croatia and Serbia. Strategies of parties promoting regionalist interests in Dalmatia, Istria and Slavonia in Croatia as well as Vojvodina and Sandžak in Serbia are compared. The paper will look at how structural conditions including territorial precedents as well as ethnic compositions of the regions influence various strategies for promotion of regional interests at the state level and their success. EU integration as a legitimising factor for decentralisation and empowerment of regions especially in the post-2000 period is analysed as well.