Knowledge on how environmental challenges and solutions are integrated is increasing, which means they affect each other significantly. The organization of knowledge production is, however, increasingly segregated and internationalized by the need for effective and specialized coordinated management. Thus, while the challenges are integrated, organizational responses tend to be fragmented. Also, domestic management systems rely heavily on domestic research institutions. Domestic decision-makers are therefore increasingly exposed to complex scientific findings produced at different levels of governance by a variety of knowledge producers in different issue areas. Against this backdrop, the primary object of this new multiyear project, where this paper presents a first cut, is to improve our understanding in the changes of knowledge production and how these changes can be managed to improve systems for domestic environmental governance.